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KMID : 0355420030270020277
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Journal of Korean Academy of Oral Health
2003 Volume.27 No. 2 p.277 ~ p.288
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Effects of Caesalpinia sappan extracts on the growth, acid production, adhesion, and insoluble glucan synthesis of Streptococcus mutans
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Abstract
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Streptococcus mutans is known as the causative bacterial playing the most important role in forming plaque and it is being noticed as major causative bacteria of dental caries. Therefore, development of more effective, substantial and safe preventive agent against dental caries and periodontal disease is honestly required. The present study was designed to investigate the effect of chloroform extract(CE), n-butanol extract(BE), methanol extract(ME) and water extract(WE) of Caesalpinia sappan on the growth, acid production, adhesion, and insoluble glucan synthesis of Streptococcus mutans. The CE, BE, ME and WE decreased the growth and acid production of S. mutans than that of control, especially, the ME was more effective than other extracts. The effect of CE, BE, ME and WE on the adherences to saliva-coated hydroxyapatite bead(S-HA) were evaluated, At the concentration of 2,000 pg/ml, the CE showed 32% rate of bacterial adherence to S-HA, whereas, other extracts of the same concentration produced greater than 50% rate. The CE and BE were significantly decreased the reduction rates of water insoluble glucan formation from sucrose by crude glucosyltransferase of S. mutans. Thus, the application of C. sappan can be considered a useful and a practical method for the prevention of dental caries.
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